The application of dried blood spot sampling in global clinical trials
نویسندگان
چکیده
منابع مشابه
Validation and Application of a Dried Blood Spot Ceftriaxone Assay.
Dried blood spot (DBS) antibiotic assays can facilitate pharmacokinetic/pharmacodynamic (PK/PD) studies in situations where venous blood sampling is logistically and/or ethically problematic. In this study, we aimed to develop, validate, and apply a DBS ceftriaxone assay. A liquid chromatography-tandem mass spectroscopy (LC-MS/MS) DBS ceftriaxone assay was assessed for matrix effects, process e...
متن کاملClinical evaluation of a dried blood spot assay for atazanavir.
Current procedures for obtaining and measuring plasma concentrations of HIV protease inhibitors (PIs) are technically challenging. Dried blood spot (DBS) assays offer a way to overcome many of the obstacles. We sought to develop a DBS assay for quantitation of the PI atazanavir (ATV) and to compare this method with a previously validated plasma assay. We prospectively enrolled 48 patients with ...
متن کاملCapillary Microsampling of Mouse Blood in Early Pre-Clinical Studies: A Preferred Alternative to Dried Blood Spot Sampling
Pre-clinical pharmacokinetic (PK) studies establish the key parameters of clearance, volume of distribution and oral bioavailability for novel chemical entities in drug discovery. Following favourable in vitro screens for metabolism and permeability, early in vivo evaluation ensures that chemical series and potential drug candidates with poor in vivo profiles are deprioritised early, focusing p...
متن کاملThe use of dried blood spot sampling for the measurement of HbA1c: a cross-sectional study
BACKGROUND The use of dried blood spot (DBS) sampling is an alternative to traditional venous blood collection, and particularly useful for people living in rural and remote areas, and for those who are infirm, house-bound or time-poor. The objective of this study was to assess whether the measurement of glycated haemoglobin A1c (HbA1c) in DBS samples provided comparative and acceptably precise...
متن کاملClinical Validation and Implications of Dried Blood Spot Sampling of Carbamazepine, Valproic Acid and Phenytoin in Patients with Epilepsy
To facilitate therapeutic monitoring of antiepileptic drugs (AEDs) by healthcare professionals for patients with epilepsy (PWE), we applied a GC-MS assay to measure three AEDs: carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) levels concurrently in one dried blood spot (DBS), and validated the DBS-measured levels to their plasma levels. 169 PWE on either mono- or polytherapy of CBZ,...
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ژورنال
عنوان ژورنال: Bioanalysis
سال: 2010
ISSN: 1757-6180,1757-6199
DOI: 10.4155/bio.10.158